Exploration of thioridazine-induced Ca2+ signaling and non-Ca2+-triggered cell death in HepG2 human hepatocellular carcinoma cells

Exploration of thioridazine-induced Ca2+ signaling and non-Ca2+-triggered cell death in HepG2 human hepatocellular carcinoma cells

Thioridazine, belonging to first-generation antipsychotic drugs, is a prescription used to treat schizophrenia. However, the effect of thioridazine on intracellular Ca2+ concentration ([Ca2+]i) and viability in human liver cancer cells is unclear. This study examined whether thioridazine altered Ca2...

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Bibliographic Details
Main Authors: I-Shu Chen, Wei-Zhe Liang, Jue-Long Wang, Chun-Chi Kuo, Lyh-Jyh Hao, Chiang-Ting Chou, Chung-Ren Jan
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2020-01-01
Series:Chinese Journal of Physiology
Subjects:
ca2+
fura-2
human hepatoma cells
thioridazine
Online Access:http://www.cjphysiology.org/article.asp?issn=0304-4920;year=2020;volume=63;issue=4;spage=187;epage=194;aulast=Chen

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http://www.cjphysiology.org/article.asp?issn=0304-4920;year=2020;volume=63;issue=4;spage=187;epage=194;aulast=Chen

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