Proteasome inhibitors prevent cell death and prolong survival of mice challenged by Shiga toxin

Proteasome inhibitors prevent cell death and prolong survival of mice challenged by Shiga toxin

Shiga toxin (Stx) causes fatal systemic complications. Stx induces apoptosis, but the mechanism of which is unclear. We report that Stx induced rapid reduction of short‐lived anti‐apoptotic proteins followed by activation of caspase 9 and the progression of apoptosis. Proteasome inhibitors prevented...

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Bibliographic Details
Main Authors: Takayuki Hattori, Miho Watanabe-Takahashi, Nobumichi Ohoka, Takashi Hamabata, Koichi Furukawa, Kiyotaka Nishikawa, Mikihiko Naito
Format: Article
Language:English
Published: Wiley 2015-01-01
Series:FEBS Open Bio
Subjects:
Shiga toxin
Apoptosis
Apoptosis inhibitory proteins
Proteasome
Proteasome inhibitor
Online Access:https://doi.org/10.1016/j.fob.2015.06.005

Internet

https://doi.org/10.1016/j.fob.2015.06.005

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