Single-cell transcriptomics reveals the cell fate transitions of human dopaminergic progenitors derived from hESCs

Single-cell transcriptomics reveals the cell fate transitions of human dopaminergic progenitors derived from hESCs

Abstract Background Midbrain dopaminergic (DA) progenitors derived from human pluripotent stem cells are considered to be a promising treatment for Parkinson’s disease (PD). However, the differentiation process produces undesired cell types, which influence the in vivo evaluation of DA cells. In thi...

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Bibliographic Details
Main Authors: Lingmin Liang, Yao Tian, Lin Feng, Chaoqun Wang, Guihai Feng, Glyn Nigel Stacey, Ng Shyh-Chang, Jun Wu, Baoyang Hu, Wei Li, Jie Hao, Liu Wang, Yukai Wang
Format: Article
Language:English
Published: BMC 2022-08-01
Series:Stem Cell Research & Therapy
Subjects:
Dopaminergic (DA) neurons
Pluripotent stem cells (PSCs)
Single-cell RNA sequencing (scRNA-seq)
Cell therapy
Parkinson’s disease (PD)
Online Access:https://doi.org/10.1186/s13287-022-03104-7

Internet

https://doi.org/10.1186/s13287-022-03104-7

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