Cetuximab reconstitutes proinflammatory cytokine secretions and tumour-infiltrating capabilities of sMICA-inhibited NK cells in HNSCC tumour spheroids.

Cetuximab reconstitutes proinflammatory cytokine secretions and tumour-infiltrating capabilities of sMICA-inhibited NK cells in HNSCC tumour spheroids.

Immunosuppressive factors, such as soluble major histocompatibility complex class I chain-related peptide A (sMICA) and transforming growth factor beta 1 (TGF-beta1), are involved in tumour immune escape mechanisms (TIEMs) exhibited by head and neck squamous cell carcinomas (HNSCCs) and may represen...

Full description

Bibliographic Details
Main Authors: Stephan eKloess, Nicole eChambron, Tanja eGardlowski, Sandra eWeil, Joachim eKoch, Ruth eEsser, Elke ePogge-von-Strandmann, Michael A. Morgan, Lubomir eArseniev, Oliver eSeitz, Ulrike eKoehl
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-11-01
Series:Frontiers in Immunology
Subjects:
ADCC
TGF-beta
Soluble MICA
cetuximab-activated NK cells
HNSCC tumour spheroids
Tumour infiltrations
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00543/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00543/full

Similar Items