Distinct Inflammatory Macrophage Populations Sequentially Infiltrate Bone‐to‐Tendon Interface Tissue After Anterior Cruciate Ligament (ACL) Reconstruction Surgery in Mice

Distinct Inflammatory Macrophage Populations Sequentially Infiltrate Bone‐to‐Tendon Interface Tissue After Anterior Cruciate Ligament (ACL) Reconstruction Surgery in Mice

ABSTRACT Macrophages are important for repair of injured tissues, but their role in healing after surgical repair of musculoskeletal tissues is not well understood. We used single‐cell RNA sequencing (RNA‐seq), flow cytometry, and transcriptomics to characterize functional phenotypes of macrophages...

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Bibliographic Details
Main Authors: Takayuki Fujii, Susumu Wada, Camila B. Carballo, Richard D. Bell, Wataru Morita, Yusuke Nakagawa, Yake Liu, Daoyun Chen, Tania Pannellini, Upneet K. Sokhi, Xiang‐hua Deng, Kyung Hyung Park‐Min, Scott A. Rodeo, Lionel B. Ivashkiv
Format: Article
Language:English
Published: Oxford University Press 2022-07-01
Series:JBMR Plus
Subjects:
SYSTEMS BIOLOGY ‐ BONE INTERACTORS
OSTEOIMMUNOLOGY
ANIMAL MODELS
ORTHOPAEDICS
INJURY/FRACTURE HEALING
Online Access:https://doi.org/10.1002/jbm4.10635

Internet

https://doi.org/10.1002/jbm4.10635

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