Role of Trypanosoma cruzi trans-sialidase on the escape of host immune surveillance
Chagas disease is caused by the flagellate protozoan Trypanosoma cruzi, affecting millions of people throughout Latin America. The parasite dampens host immune response causing modifications in diverse lymphoid compartments, including the thymus. T. cruzi trans-sialidase (TS) seems to play a fundame...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2016-03-01
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| Series: | Frontiers in Microbiology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fmicb.2016.00348/full |
| _version_ | 1811306655394037760 |
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| author | Ana Flávia Fernandes Ribas Nardy Celio Geraldo Freire De Lima Ana Rosa ePérez Alexandre eMorrot |
| author_facet | Ana Flávia Fernandes Ribas Nardy Celio Geraldo Freire De Lima Ana Rosa ePérez Alexandre eMorrot |
| author_sort | Ana Flávia Fernandes Ribas Nardy |
| collection | DOAJ |
| description | Chagas disease is caused by the flagellate protozoan Trypanosoma cruzi, affecting millions of people throughout Latin America. The parasite dampens host immune response causing modifications in diverse lymphoid compartments, including the thymus. T. cruzi trans-sialidase (TS) seems to play a fundamental role in such immunopathological events. This unusual enzyme catalysed the transference of sialic acid molecules from host glycoconjugates to acceptor molecules placed on the parasite surface. TS activity mediates several biological effects leading to the subversion of the host immune system, favouring both parasite survival and the establishment of chronic infection. This review summarizes current findings on the role of TS on the immune response during T. cruzi infection. |
| first_indexed | 2024-04-13T08:49:22Z |
| format | Article |
| id | doaj.art-ebfc964be1114840ab318f53507af881 |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-04-13T08:49:22Z |
| publishDate | 2016-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-ebfc964be1114840ab318f53507af8812022-12-22T02:53:33ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2016-03-01710.3389/fmicb.2016.00348179100Role of Trypanosoma cruzi trans-sialidase on the escape of host immune surveillanceAna Flávia Fernandes Ribas Nardy0Celio Geraldo Freire De Lima1Ana Rosa ePérez2Alexandre eMorrot3Universidade Federal do Rio de JaneiroUniversidade Federal do Rio de JaneiroNational University of RosarioUniversidade Federal do Rio de JaneiroChagas disease is caused by the flagellate protozoan Trypanosoma cruzi, affecting millions of people throughout Latin America. The parasite dampens host immune response causing modifications in diverse lymphoid compartments, including the thymus. T. cruzi trans-sialidase (TS) seems to play a fundamental role in such immunopathological events. This unusual enzyme catalysed the transference of sialic acid molecules from host glycoconjugates to acceptor molecules placed on the parasite surface. TS activity mediates several biological effects leading to the subversion of the host immune system, favouring both parasite survival and the establishment of chronic infection. This review summarizes current findings on the role of TS on the immune response during T. cruzi infection.http://journal.frontiersin.org/Journal/10.3389/fmicb.2016.00348/fullImmune EvasionParasitestrans-sialidaseGlycoimmunologyTrypanosama cruzi |
| spellingShingle | Ana Flávia Fernandes Ribas Nardy Celio Geraldo Freire De Lima Ana Rosa ePérez Alexandre eMorrot Role of Trypanosoma cruzi trans-sialidase on the escape of host immune surveillance Frontiers in Microbiology Immune Evasion Parasites trans-sialidase Glycoimmunology Trypanosama cruzi |
| title | Role of Trypanosoma cruzi trans-sialidase on the escape of host immune surveillance |
| title_full | Role of Trypanosoma cruzi trans-sialidase on the escape of host immune surveillance |
| title_fullStr | Role of Trypanosoma cruzi trans-sialidase on the escape of host immune surveillance |
| title_full_unstemmed | Role of Trypanosoma cruzi trans-sialidase on the escape of host immune surveillance |
| title_short | Role of Trypanosoma cruzi trans-sialidase on the escape of host immune surveillance |
| title_sort | role of trypanosoma cruzi trans sialidase on the escape of host immune surveillance |
| topic | Immune Evasion Parasites trans-sialidase Glycoimmunology Trypanosama cruzi |
| url | http://journal.frontiersin.org/Journal/10.3389/fmicb.2016.00348/full |
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