Immunogenicity and protective efficacy of RSV G central conserved domain vaccine with a prefusion nanoparticle

Immunogenicity and protective efficacy of RSV G central conserved domain vaccine with a prefusion nanoparticle

Abstract Respiratory syncytial virus (RSV) G glycoprotein has recently reemerged as a vaccine antigen due to its ability to elicit potent neutralizing antibodies and ameliorate disease in animal models. Here we designed three constructs to display the G central conserved domain (Gcc) focused on indu...

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Bibliographic Details
Main Authors: Jennifer N. Rainho-Tomko, Vincent Pavot, Michael Kishko, Kurt Swanson, Darin Edwards, Heesik Yoon, Lilibeth Lanza, Judith Alamares-Sapuay, Robert Osei-Bonsu, Sophia T. Mundle, Dave A. Murison, Scott Gallichan, Simon Delagrave, Chih-Jen Wei, Linong Zhang, Gary J. Nabel
Format: Article
Language:English
Published: Nature Portfolio 2022-06-01
Series:npj Vaccines
Online Access:https://doi.org/10.1038/s41541-022-00487-9

Internet

https://doi.org/10.1038/s41541-022-00487-9

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