Clinical application of RUBCN/SESN2 mediated inhibition of autophagy as biomarkers of diabetic kidney disease

Clinical application of RUBCN/SESN2 mediated inhibition of autophagy as biomarkers of diabetic kidney disease

Abstract Background Deregulated autophagy in diabetes has been a field of many experimental studies recently. Impaired autophagy in diabetic kidneys orchestrates every step of diabetic nephropathy (DN) pathogenesis. This study aimed to evaluate three autophagy regulators; RUBCN, mTOR, and SESN2 as c...

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Bibliographic Details
Main Authors: Mona M. Watany, Hemat E. El-Horany, Marwa M. Elhosary, Ahmed A. Elhadidy
Format: Article
Language:English
Published: BMC 2022-12-01
Series:Molecular Medicine
Subjects:
Diabetic nephropathy
Autophagy
Mammalian/mechanistic target of rapamycin (mTOR)
Rubicon (RUBCN)
Sestrin-2 (SESN2)
Insulin resistance, glycemic control
Online Access:https://doi.org/10.1186/s10020-022-00580-8

Internet

https://doi.org/10.1186/s10020-022-00580-8

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