Novel multiplex PCR-SSP method for centromeric KIR allele discrimination

Novel multiplex PCR-SSP method for centromeric KIR allele discrimination

Abstract Allelic diversity of the KIR2DL receptors drive differential expression and ligand-binding affinities that impact natural killer cell function and patient outcomes for diverse cancers. We have developed a global intermediate resolution amplification-refractory mutation system (ARMS) PCR-SSP...

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Bibliographic Details
Main Authors: Jean-Benoît Le Luduec, Anupa Kudva, Jeanette E. Boudreau, Katharine C. Hsu
Format: Article
Language:English
Published: Nature Portfolio 2018-10-01
Series:Scientific Reports
Subjects:
Killer Cell Immunoglobulin-like Receptors
KIR3DL1 Alleles
Receptor KIR2DL4
Amplification-refractory Mutation System (ARMS)
Centre d’Etude Polymorphisme Humain (CEPH)
Online Access:https://doi.org/10.1038/s41598-018-33135-1

Internet

https://doi.org/10.1038/s41598-018-33135-1

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