<i>DOCK2</i> Mutation and Recurrent Hemophagocytic Lymphohistiocytosis

<i>DOCK2</i> Mutation and Recurrent Hemophagocytic Lymphohistiocytosis

Hemophagocytic lymphohistiocytosis (HLH) is a syndrome resulting from uncontrolled hyper-inflammation, excessive immune system activation, and elevated levels of inflammatory cytokines. HLH can be caused by the inability to downregulate activated macrophages by natural killer (NK) and CD8 cytotoxic...

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Bibliographic Details
Main Authors: Daniel D. Reiff, Mingce Zhang, Randy Q. Cron
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Life
Subjects:
hemophagocytic lymphohistiocytosis
inflammation
natural killer cell
macrophage
cytolysis
degranulation
Online Access:https://www.mdpi.com/2075-1729/13/2/434

Internet

https://www.mdpi.com/2075-1729/13/2/434

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