Inhibiting G6PD by quercetin promotes degradation of EGFR T790M mutation

Inhibiting G6PD by quercetin promotes degradation of EGFR T790M mutation

Summary: EGFRT790M mutation causes resistance to the first-generation tyrosine kinase inhibitors (TKIs) in patients with non-small cell lung cancer (NSCLC). However, the therapeutic options for sensitizing first TKIs and delaying the emergence of EGFRT790M mutant are limited. In this study, we show...

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Bibliographic Details
Main Authors: Zehe Ge, Miao Xu, Yuqian Ge, Guang Huang, Dongyin Chen, Xiuquan Ye, Yibei Xiao, Hongyu Zhu, Rong Yin, Hua Shen, Gaoxiang Ma, Lianwen Qi, Guining Wei, Dongmei Li, Shaofeng Wei, Meng Zhu, Hongxia Ma, Zhumei Shi, Xiuxing Wang, Xin Ge, Xu Qian
Format: Article
Language:English
Published: Elsevier 2023-11-01
Series:Cell Reports
Subjects:
CP: Cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723014298

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http://www.sciencedirect.com/science/article/pii/S2211124723014298

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