Potential Role of the Host-Derived Cell-Wall Binding Domain of Endolysin CD16/50L as a Molecular Anchor in Preservation of Uninfected Clostridioides difficile for New Rounds of Phage Infection

Potential Role of the Host-Derived Cell-Wall Binding Domain of Endolysin CD16/50L as a Molecular Anchor in Preservation of Uninfected Clostridioides difficile for New Rounds of Phage Infection

ABSTRACT Endolysin is a phage-encoded cell-wall hydrolase which degrades the peptidoglycan layer of the bacterial cell wall. The enzyme is often expressed at the late stage of the phage lytic cycle and is required for progeny escape. Endolysins of bacteriophage that infect Gram-positive bacteria oft...

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Bibliographic Details
Main Authors: Wichuda Phothichaisri, Surang Chankhamhaengdecha, Tavan Janvilisri, Jirayu Nuadthaisong, Tanaporn Phetruen, Robert P. Fagan, Sittinan Chanarat
Format: Article
Language:English
Published: American Society for Microbiology 2022-04-01
Series:Microbiology Spectrum
Subjects:
Clostridioides difficile
endolysin
cell-wall binding domain
peptidoglycan
surface layer
bacteria-phage coevolution
Online Access:https://journals.asm.org/doi/10.1128/spectrum.02361-21

Internet

https://journals.asm.org/doi/10.1128/spectrum.02361-21

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