Macrophage LMO7 deficiency facilitates inflammatory injury via metabolic-epigenetic reprogramming

Macrophage LMO7 deficiency facilitates inflammatory injury via metabolic-epigenetic reprogramming

Inflammatory bowel disease (IBD) is a formidable disease due to its complex pathogenesis. Macrophages, as a major immune cell population in IBD, are crucial for gut homeostasis. However, it is still unveiled how macrophages modulate IBD. Here, we found that LIM domain only 7 (LMO7) was downregulated...

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Bibliographic Details
Main Authors: Shixin Duan, Xinyi Lou, Shiyi Chen, Hongchao Jiang, Dongxin Chen, Rui Yin, Mengkai Li, Yuseng Gou, Wenjuan Zhao, Lei Sun, Feng Qian
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Inflammatory bowel disease
Macrophage
LMO7
Ubiquitination
PFKFB3
JMJD3
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383523003659

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http://www.sciencedirect.com/science/article/pii/S2211383523003659

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