Listeria exploits IFITM3 to suppress antibacterial activity in phagocytes
Interferon (IFN) is an important component of antiviral immunity, but can also be exploited by bacteria for immune evasion. Here the authors show that Listeria monocytogenes (Lm) induces type I IFN to suppress the degradation of Lm virulence proteins, ActA and LLO, and promote Lm infection in an IFI...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-08-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-24982-0 |
| _version_ | 1818843977679372288 |
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| author | Joel M. J. Tan Monica E. Garner James M. Regeimbal Catherine J. Greene Jorge D. Rojas Márquez Dustin A. Ammendolia Adam R. R. McCluggage Taoyingnan Li Katherine J. Wu Marija Cemma Philip P. Ostrowski Brian Raught Michael S. Diamond Sergio Grinstein Robin M. Yates Darren E. Higgins John H. Brumell |
| author_facet | Joel M. J. Tan Monica E. Garner James M. Regeimbal Catherine J. Greene Jorge D. Rojas Márquez Dustin A. Ammendolia Adam R. R. McCluggage Taoyingnan Li Katherine J. Wu Marija Cemma Philip P. Ostrowski Brian Raught Michael S. Diamond Sergio Grinstein Robin M. Yates Darren E. Higgins John H. Brumell |
| author_sort | Joel M. J. Tan |
| collection | DOAJ |
| description | Interferon (IFN) is an important component of antiviral immunity, but can also be exploited by bacteria for immune evasion. Here the authors show that Listeria monocytogenes (Lm) induces type I IFN to suppress the degradation of Lm virulence proteins, ActA and LLO, and promote Lm infection in an IFITM3-dependent manner, thereby hinting at a potential target for antimicrobial therapy. |
| first_indexed | 2024-12-19T05:06:27Z |
| format | Article |
| id | doaj.art-ec11a9708c984975be93768c9db2c7f1 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-19T05:06:27Z |
| publishDate | 2021-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-ec11a9708c984975be93768c9db2c7f12022-12-21T20:34:57ZengNature PortfolioNature Communications2041-17232021-08-0112111510.1038/s41467-021-24982-0Listeria exploits IFITM3 to suppress antibacterial activity in phagocytesJoel M. J. Tan0Monica E. Garner1James M. Regeimbal2Catherine J. Greene3Jorge D. Rojas Márquez4Dustin A. Ammendolia5Adam R. R. McCluggage6Taoyingnan Li7Katherine J. Wu8Marija Cemma9Philip P. Ostrowski10Brian Raught11Michael S. Diamond12Sergio Grinstein13Robin M. Yates14Darren E. Higgins15John H. Brumell16Cell Biology Program, Hospital for Sick ChildrenCell Biology Program, Hospital for Sick ChildrenDepartment of Microbiology, Blavatnik Institute, Harvard Medical SchoolDepartment of Biochemistry and Molecular Biology, University of CalgaryCell Biology Program, Hospital for Sick ChildrenCell Biology Program, Hospital for Sick ChildrenCell Biology Program, Hospital for Sick ChildrenCell Biology Program, Hospital for Sick ChildrenDepartment of Microbiology, Blavatnik Institute, Harvard Medical SchoolCell Biology Program, Hospital for Sick ChildrenCell Biology Program, Hospital for Sick ChildrenPrincess Margaret Cancer Centre, University Health NetworkDepartments of Medicine, Molecular Microbiology, Pathology & Immunology, Washington University School of MedicineCell Biology Program, Hospital for Sick ChildrenDepartment of Biochemistry and Molecular Biology, University of CalgaryDepartment of Microbiology, Blavatnik Institute, Harvard Medical SchoolCell Biology Program, Hospital for Sick ChildrenInterferon (IFN) is an important component of antiviral immunity, but can also be exploited by bacteria for immune evasion. Here the authors show that Listeria monocytogenes (Lm) induces type I IFN to suppress the degradation of Lm virulence proteins, ActA and LLO, and promote Lm infection in an IFITM3-dependent manner, thereby hinting at a potential target for antimicrobial therapy.https://doi.org/10.1038/s41467-021-24982-0 |
| spellingShingle | Joel M. J. Tan Monica E. Garner James M. Regeimbal Catherine J. Greene Jorge D. Rojas Márquez Dustin A. Ammendolia Adam R. R. McCluggage Taoyingnan Li Katherine J. Wu Marija Cemma Philip P. Ostrowski Brian Raught Michael S. Diamond Sergio Grinstein Robin M. Yates Darren E. Higgins John H. Brumell Listeria exploits IFITM3 to suppress antibacterial activity in phagocytes Nature Communications |
| title | Listeria exploits IFITM3 to suppress antibacterial activity in phagocytes |
| title_full | Listeria exploits IFITM3 to suppress antibacterial activity in phagocytes |
| title_fullStr | Listeria exploits IFITM3 to suppress antibacterial activity in phagocytes |
| title_full_unstemmed | Listeria exploits IFITM3 to suppress antibacterial activity in phagocytes |
| title_short | Listeria exploits IFITM3 to suppress antibacterial activity in phagocytes |
| title_sort | listeria exploits ifitm3 to suppress antibacterial activity in phagocytes |
| url | https://doi.org/10.1038/s41467-021-24982-0 |
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