Metformin impairs trophoblast metabolism and differentiation in a dose-dependent manner

Metformin impairs trophoblast metabolism and differentiation in a dose-dependent manner

Metformin is a widely prescribed medication whose mechanism of action is not completely defined and whose role in gestational diabetes management remains controversial. In addition to increasing the risk of fetal growth abnormalities and preeclampsia, gestational diabetes is associated with abnormal...

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Bibliographic Details
Main Authors: Sereen K. Nashif, Renee M. Mahr, Snehalata Jena, Seokwon Jo, Alisa B. Nelson, Danielle Sadowski, Peter A. Crawford, Patrycja Puchalska, Emilyn U. Alejandro, Micah D. Gearhart, Sarah A. Wernimont
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
metformin
metabolism
trophoblast stem cell
BeWo
cytotrophoblast
syncytiotrophoblast
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2023.1167097/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2023.1167097/full

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