A High-Throughput Method for Screening for Genes Controlling Bacterial Conjugation of Antibiotic Resistance

A High-Throughput Method for Screening for Genes Controlling Bacterial Conjugation of Antibiotic Resistance

ABSTRACT The rapid horizontal transmission of antibiotic resistance genes on conjugative plasmids between bacterial host cells is a major cause of the accelerating antibiotic resistance crisis. There are currently no experimental platforms for fast and cost-efficient screening of genetic effects on...

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Bibliographic Details
Main Authors: Hanna Alalam, Fabrice E. Graf, Martin Palm, Marie Abadikhah, Martin Zackrisson, Jonas Boström, Alfred Fransson, Chris Hadjineophytou, Linnéa Persson, Simon Stenberg, Matilda Mattsson, Payam Ghiaci, Per Sunnerhagen, Jonas Warringer, Anne Farewell
Format: Article
Language:English
Published: American Society for Microbiology 2020-12-01
Series:mSystems
Subjects:
high-throughput screening
antibiotic resistance
conjugation
horizontal transmission
plasmid
horizontal gene transfer
Online Access:https://journals.asm.org/doi/10.1128/mSystems.01226-20

Internet

https://journals.asm.org/doi/10.1128/mSystems.01226-20

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