Lack of dystrophin leads to the selective loss of superior cervical ganglion neurons projecting to muscular targets in genetically dystrophic mdx mice

Lack of dystrophin leads to the selective loss of superior cervical ganglion neurons projecting to muscular targets in genetically dystrophic mdx mice

Autonomic imbalance is a pathological aspect of Duchenne muscular dystrophy. Here, we show that the sympathetic superior cervical ganglion (SCG) of mdx mice, which lack dystrophin (Dp427), has 36% fewer neurons than that of wild-type animals. Cell loss occurs around P10 and affects those neurons inn...

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Bibliographic Details
Main Authors: M. Egle De Stefano, Lucia Leone, Loredana Lombardi, Paola Paggi
Format: Article
Language:English
Published: Elsevier 2005-12-01
Series:Neurobiology of Disease
Subjects:
Neuropathology
Sympathetic nervous system
Iris
Submandibular gland
Tyrosine hydroxylase
Muscular dystrophy
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996105001634

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http://www.sciencedirect.com/science/article/pii/S0969996105001634

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