Marked QTc prolongation and Torsades de Pointes in patients with chronic inflammatory arthritis

Marked QTc prolongation and Torsades de Pointes in patients with chronic inflammatory arthritis

Mounting evidence indicates that in chronic inflammatory arthritis (CIA), QTc prolongation is frequent and correlates with systemic inflammatory activation. Notably, basic studies demonstrated that inflammatory cytokines induce profound changes in potassium and calcium channels resulting in a prolon...

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Bibliographic Details
Main Authors: Pietro Enea Lazzerini, Pier Leopoldo Capecchi, Iacopo Bertolozzi, Gabriella Morozzi, Sauro Lorenzini, Antonella Simpatico, Selvi Enrico, Maria Romana Bacarelli, Maurizio Acampa, Deana Lazaro, Nabil El-Sherif, Mohamed Boutjdir, Franco Laghi-Pasini
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-09-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
Interleukin-6
Torsades de Pointes
sudden death
systemic inflammation
Chronic inflammatory arthritis
Online Access:http://journal.frontiersin.org/Journal/10.3389/fcvm.2016.00031/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fcvm.2016.00031/full

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