Novel 4-Azapregnene Derivatives as Potential Anticancer Agents: Synthesis, Antiproliferative Activity and Molecular Docking Studies

A series of novel 21<i>E</i>-arylidene-4-azapregn-5-ene steroids has been successfully designed, synthesized and structurally characterized, and their antiproliferative activity was evaluated in four different cell lines. Within this group, the 21<i>E</i>-(pyridin-3-yl)methyl...

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Bibliographic Details
Main Authors: Vanessa Brito, Adriana Oliveira Santos, Gilberto Alves, Paulo Almeida, Samuel Silvestre
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Molecules
Subjects:
Online Access:https://www.mdpi.com/1420-3049/27/18/6126