Mutation analysis of BCR-ABL1 kinase domain in chronic myeloid leukemia patients with tyrosine kinase inhibitors resistance: a Malaysian cohort study

Mutation analysis of BCR-ABL1 kinase domain in chronic myeloid leukemia patients with tyrosine kinase inhibitors resistance: a Malaysian cohort study

Abstract Objective Mutational analysis of BCR::ABL1 kinase domain (KD) is a crucial component of clinical decision algorithms for chronic myeloid leukemia (CML) patients with failure or warning responses to tyrosine kinase inhibitor (TKI) therapy. This study aimed to detect BCR::ABL1 KD mutations in...

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Bibliographic Details
Main Authors: Zahidah Abu Seman, Fadly Ahid, Nor Rizan Kamaluddin, Ermi Neiza Mohd Sahid, Ezalia Esa, Siti Shahrum Muhamed Said, Norazlina Azman, Wan Khairull Dhalila Wan Mat, Julia Abdullah, Nurul Aqilah Ali, Mohd Khairul Nizam Mohd Khalid, Yuslina Mat Yusoff
Format: Article
Language:English
Published: BMC 2024-04-01
Series:BMC Research Notes
Subjects:
Chronic myeloid leukemia
BCR:ABL1 KD mutation
TKI resistance
Next generation sequencing
Sanger sequencing
Online Access:https://doi.org/10.1186/s13104-024-06772-1

Internet

https://doi.org/10.1186/s13104-024-06772-1

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