Alleviation of Endoplasmic Reticulum Stress Enhances Human Corneal Epithelial Cell Viability under Hyperosmotic Conditions

Alleviation of Endoplasmic Reticulum Stress Enhances Human Corneal Epithelial Cell Viability under Hyperosmotic Conditions

Tear hyperosmolarity plays an essential role in the initiation and progression of dry-eye disease. Under a hyperosmotic environment, corneal epithelial cells experience perturbations in endoplasmic reticulum function that can lead to proinflammatory signaling and apoptosis. In this study, we investi...

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Bibliographic Details
Main Authors: Damien Guindolet, Ashley M. Woodward, Eric E. Gabison, Pablo Argüeso
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:International Journal of Molecular Sciences
Subjects:
corneal epithelium
dry eye
endoplasmic reticulum stress
hyperosmotic stress
tauroursodeoxycholic acid
unfolded protein response
Online Access:https://www.mdpi.com/1422-0067/23/9/4528

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https://www.mdpi.com/1422-0067/23/9/4528

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