Gain- and Loss-of-Function <i>CFTR</i> Alleles Are Associated with COVID-19 Clinical Outcomes

Gain- and Loss-of-Function <i>CFTR</i> Alleles Are Associated with COVID-19 Clinical Outcomes

Carriers of single pathogenic variants of the <i>CFTR</i> (cystic fibrosis transmembrane conductance regulator) gene have a higher risk of severe COVID-19 and 14-day death. The machine learning post-Mendelian model pinpointed <i>CFTR</i> as a bidirectional modulator of COVID-...

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Bibliographic Details
Main Authors: Margherita Baldassarri, Kristina Zguro, Valeria Tomati, Cristina Pastorino, Francesca Fava, Susanna Croci, Mirella Bruttini, Nicola Picchiotti, Simone Furini, GEN-COVID Multicenter Study, Nicoletta Pedemonte, Chiara Gabbi, Alessandra Renieri, Chiara Fallerini
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Cells
Subjects:
COVID-19
<i>CFTR</i> complex alleles
post-Mendelian model
Online Access:https://www.mdpi.com/2073-4409/11/24/4096

Internet

https://www.mdpi.com/2073-4409/11/24/4096

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