Overexpression of GDNF in Spinal Cord Attenuates Morphine Analgesic Tolerance in Rats with Bone Cancer Pain

Overexpression of GDNF in Spinal Cord Attenuates Morphine Analgesic Tolerance in Rats with Bone Cancer Pain

Bone cancer pain (BCP) is one of the typical and distressing symptoms in cancer patients. Morphine is a widely used analgesic drug for BCP; however, long-term morphine administration will lead to analgesic tolerance. Our previous study indicated that spinal glial cell line-derived neurotrophic facto...

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Bibliographic Details
Main Authors: Wei Xu, Zhuofeng Ding, Zongbin Song, Jian Wang, Jie Zhang, Wangyuan Zou
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Brain Sciences
Subjects:
bone cancer pain
morphine tolerance
glial cell line-derived neurotrophic factor
MOR
spinal
Online Access:https://www.mdpi.com/2076-3425/12/9/1188

Internet

https://www.mdpi.com/2076-3425/12/9/1188

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