Oral treatment of 4-methylumbelliferone reduced perineuronal nets and improved recognition memory in mice

Oral treatment of 4-methylumbelliferone reduced perineuronal nets and improved recognition memory in mice

Hyaluronan (HA) is a core constituent of perineuronal nets (PNNs) that surround subpopulations of neurones. The PNNs control synaptic stabilization in both the developing and adult central nervous system, and disruption of PNNs has shown to reactivate neuroplasticity. We investigated the possibility...

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Bibliographic Details
Main Authors: Jana Dubisova, Jana Svobodova Burianova, Lucie Svobodova, Pavol Makovicky, Noelia Martinez-Varea, Anda Cimpean, James W. Fawcett, Jessica C.F. Kwok, Sarka Kubinova
Format: Article
Language:English
Published: Elsevier 2022-04-01
Series:Brain Research Bulletin
Subjects:
Perineuronal net
Hyaluronan
Memory
Neuroplasticity
Extracellular matrix
Online Access:http://www.sciencedirect.com/science/article/pii/S0361923022000132

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http://www.sciencedirect.com/science/article/pii/S0361923022000132

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