Combined mutations of the penA with ftsX genes contribute to ceftriaxone resistance in Neisseria gonorrhoeae and peptide nucleic acids targeting these genes reverse ceftriaxone resistance

Combined mutations of the penA with ftsX genes contribute to ceftriaxone resistance in Neisseria gonorrhoeae and peptide nucleic acids targeting these genes reverse ceftriaxone resistance

ABSTRACT: Objectives: To investigate the gene mutations associated with ceftriaxone (CRO) resistance among gonococcal isolates, and to determine the effects of the mutated genes on CRO minimum inhibitory concentrations (MICs) with transformation assays and antisense peptide nucleic acids (asPNAs)....

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Bibliographic Details
Main Authors: Lin Zhu, Jingyao Liang, Yue Zheng, Shaochun Chen, Qingfang Xu, Songchao Yin, Yiyong Hong, Wenling Cao, Wei Lai, Zijian Gong
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:Journal of Global Antimicrobial Resistance
Subjects:
ftsX
penA
Neisseria gonorrhoeae
ceftriaxone resistance
antisense peptide nucleic acid
Online Access:http://www.sciencedirect.com/science/article/pii/S2213716523001297

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http://www.sciencedirect.com/science/article/pii/S2213716523001297

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