A conjugate of an anti-midkine single-chain variable fragment to doxorubicin inhibits tumor growth

A conjugate of an anti-midkine single-chain variable fragment to doxorubicin inhibits tumor growth

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Doxorubicin (DOX) was conjugated to a single-chain variable fragment (scFv) against human midkine (MK), and the conjugate (scFv-DOX) was used to target the chemotherapeutic agent to a mouse solid tumor model in which the tumor cells expressed high levels of human MK. The His-tagged recombinant scFv...

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Bibliographic Details
Main Authors: Shuli Zhao, Guangfeng Zhao, Hao Xie, Yahong Huang, Yayi Hou
Format: Article
Language:English
Published: Associação Brasileira de Divulgação Científica 2012-03-01
Series:Brazilian Journal of Medical and Biological Research
Subjects:
Single-chain variable fragments
Midkine
Tumor targeting
Doxorubicin
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012000300008

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012000300008

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