REstricted Fluid REsuscitation in Sepsis-associated Hypotension (REFRESH): study protocol for a pilot randomised controlled trial

REstricted Fluid REsuscitation in Sepsis-associated Hypotension (REFRESH): study protocol for a pilot randomised controlled trial

Abstract Background Guidelines recommend an initial intravenous (IV) fluid bolus of 30 ml/kg isotonic crystalloid for patients with sepsis and hypotension. However, there is a lack of evidence from clinical trials to support this. Accumulating observational data suggest harm associated with the inju...

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Bibliographic Details
Main Authors: Stephen P. J. Macdonald, David McD Taylor, Gerben Keijzers, Glenn Arendts, Daniel M. Fatovich, Frances B. Kinnear, Simon G. A. Brown, Rinaldo Bellomo, Sally Burrows, John F. Fraser, Edward Litton, Juan Carlos Ascencio-Lane, Matthew Anstey, David McCutcheon, Lisa Smart, Ioana Vlad, James Winearls, Bradley Wibrow
Format: Article
Language:English
Published: BMC 2017-08-01
Series:Trials
Subjects:
Sepsis
Fluid therapy
Hypotension
Online Access:http://link.springer.com/article/10.1186/s13063-017-2137-7

Internet

http://link.springer.com/article/10.1186/s13063-017-2137-7

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