Differential Modulation of Fast Inactivation in Cardiac Sodium Channel Splice Variants by Fyn Tyrosine Kinase

Differential Modulation of Fast Inactivation in Cardiac Sodium Channel Splice Variants by Fyn Tyrosine Kinase

Background/Aims: Post-translational modifications such as phosphorylation and dephosphorylation can finely tune the function of ion channels. Nav1.5 is the main sodium channel in human hearts and alternative splicing of the transcript generates two major splice variants, characterized by the presenc...

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Bibliographic Details
Main Authors: Shahid M. Iqbal, Gowri S.B. Andavan, Rosa Lemmens-Gruber
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2015-09-01
Series:Cellular Physiology and Biochemistry
Subjects:
Nav 1.5 channel splice variants
Fyn kinase
Phosphorylation
Online Access:http://www.karger.com/Article/FullText/430211

Internet

http://www.karger.com/Article/FullText/430211

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