Rapid Phenotypic Convergence towards Collateral Sensitivity in Clinical Isolates of Pseudomonas aeruginosa Presenting Different Genomic Backgrounds

Rapid Phenotypic Convergence towards Collateral Sensitivity in Clinical Isolates of Pseudomonas aeruginosa Presenting Different Genomic Backgrounds

ABSTRACT Collateral sensitivity (CS) is an evolutionary trade-off by which acquisition of resistance to an antibiotic leads to increased susceptibility to another. This Achilles’ heel of antibiotic resistance could be exploited to design evolution-based strategies for treating bacterial infections....

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Bibliographic Details
Main Authors: Sara Hernando-Amado, Carla López-Causapé, Pablo Laborda, Fernando Sanz-García, Antonio Oliver, José Luis Martínez
Format: Article
Language:English
Published: American Society for Microbiology 2023-02-01
Series:Microbiology Spectrum
Subjects:
Pseudomonas aeruginosa
clinical isolates
antibiotic resistance
collateral sensitivity
evolutionary robustness
quinolones
Online Access:https://journals.asm.org/doi/10.1128/spectrum.02276-22

Internet

https://journals.asm.org/doi/10.1128/spectrum.02276-22

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