Rapid Phenotypic Convergence towards Collateral Sensitivity in Clinical Isolates of Pseudomonas aeruginosa Presenting Different Genomic Backgrounds

ABSTRACT Collateral sensitivity (CS) is an evolutionary trade-off by which acquisition of resistance to an antibiotic leads to increased susceptibility to another. This Achilles’ heel of antibiotic resistance could be exploited to design evolution-based strategies for treating bacterial infections....

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Những tác giả chính: Sara Hernando-Amado, Carla López-Causapé, Pablo Laborda, Fernando Sanz-García, Antonio Oliver, José Luis Martínez
Định dạng: Bài viết
Ngôn ngữ:English
Được phát hành: American Society for Microbiology 2023-02-01
Loạt:Microbiology Spectrum
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Truy cập trực tuyến:https://journals.asm.org/doi/10.1128/spectrum.02276-22