DNMT1 downregulation as well as its overexpression distinctly affect mostly overlapping genes implicated in schizophrenia, autism spectrum, epilepsy, and bipolar disorders

DNMT1 downregulation as well as its overexpression distinctly affect mostly overlapping genes implicated in schizophrenia, autism spectrum, epilepsy, and bipolar disorders

Data on schizophrenia (SZ), epilepsy (EPD) and bipolar disorders (BPD) suggested an association of DNMT1 overexpression whereas certain variants of the gene were predicted to result in its increased expression in autism spectrum disorder (ASD). In addition, loss of DNMT1 in frontal cortex resulted i...

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Bibliographic Details
Main Authors: Minali Singh, Sonal Saxena, Kommu Naga Mohan
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-12-01
Series:Frontiers in Molecular Neuroscience
Subjects:
Dnmt1
schizophrenia
autism spectrum disorder
bipolar disorder
epilepsy
gene dysregulation
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2023.1275697/full

Internet

https://www.frontiersin.org/articles/10.3389/fnmol.2023.1275697/full

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