Relevance of Coding Variation in FLG And DOCK8 in Finnish Pediatric Patients with Early-Onset Moderate-To-Severe Atopic Dermatitis

Relevance of Coding Variation in FLG And DOCK8 in Finnish Pediatric Patients with Early-Onset Moderate-To-Severe Atopic Dermatitis

Early-onset, persistent atopic dermatitis (AD) is proposed as a distinct subgroup that may have specific genotypic features. FLG gene loss-of-function variants are the best known genetic factors contributing to epidermal barrier impairment and eczema severity. In a cohort of 140 Finnish children wit...

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Bibliographic Details
Main Authors: Miia Perälä, Meri Kaustio, Alexander Salava, Eveliina Jakkula, Anna S. Pelkonen, Janna Saarela, Anita Remitz, Mika J. Mäkelä
Format: Article
Language:English
Published: Elsevier 2023-07-01
Series:JID Innovations
Online Access:http://www.sciencedirect.com/science/article/pii/S2667026723000267

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http://www.sciencedirect.com/science/article/pii/S2667026723000267

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