Validation of a Novel EUS-FNB-Derived Organoid Co-Culture System for Drug Screening in Patients with Pancreatic Cancer

Validation of a Novel EUS-FNB-Derived Organoid Co-Culture System for Drug Screening in Patients with Pancreatic Cancer

Cancer-associated fibroblasts (CAFs) have been shown to impact the chemosensitivity of patient-derived tumor organoids (PDTOs). However, the published literature comparing PDTO response to clinical outcome does not include CAFs in the models. Here, a co-culture model was created using PDTOs and CAFs...

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Bibliographic Details
Main Authors: Simon Ezban Grützmeier, Bojan Kovacevic, Peter Vilmann, Charlotte Vestrup Rift, Linea Cecilie Melchior, Morten Orebo Holmström, Lene Brink, Hazem Hassan, John Gásdal Karstensen, Hanne Grossjohann, Deepthi Chiranth, Anders Toxværd, Carsten Palnæs Hansen, Estrid Høgdall, Jane Preuss Hasselby, Pia Klausen
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:Cancers
Subjects:
pancreatic cancer
patient-derived organoids
EUS-FNB
co-cultures
cancer-associated fibroblasts
personalized medicine
Online Access:https://www.mdpi.com/2072-6694/15/14/3677

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https://www.mdpi.com/2072-6694/15/14/3677

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