Role of the VEGF-Flt-1-FAK pathway in the pathogenesis of osteoclastic bone destruction of giant cell tumors of bone

Role of the VEGF-Flt-1-FAK pathway in the pathogenesis of osteoclastic bone destruction of giant cell tumors of bone

<p>Abstract</p> <p>Background</p> <p>Giant cell tumors (GCTs) of bone are primary benign bone tumors that are characterized by a high number of osteoclast-like multinuclear giant cells (MNCs). Recent studies suggest that the spindle-shaped stromal cells in GCTs are tumo...

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Main Authors: Harimaya Katsumi, Matsuda Shuichi, Koga Mihoko, Iida Keiichiro, Fujiwara Toshifumi, Kamura Satoshi, Fukushi Jun-ichi, Okada Yuko, Matsumoto Yoshihiro, Sakamoto Akio, Iwamoto Yukihide
Format: Article
Language:English
Published: BMC 2010-11-01
Series:Journal of Orthopaedic Surgery and Research
Online Access:http://www.josr-online.com/content/5/1/85

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http://www.josr-online.com/content/5/1/85

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