From X-ray crystallographic structure to intrinsic thermodynamics of protein–ligand binding using carbonic anhydrase isozymes as a model system

From X-ray crystallographic structure to intrinsic thermodynamics of protein–ligand binding using carbonic anhydrase isozymes as a model system

Carbonic anhydrase (CA) was among the first proteins whose X-ray crystal structure was solved to atomic resolution. CA proteins have essentially the same fold and similar active centers that differ in only several amino acids. Primary sulfonamides are well defined, strong and specific binders of CA....

Full description

Bibliographic Details
Main Authors: Vaida Paketurytė-Latvė, Alexey Smirnov, Elena Manakova, Lina Baranauskiene, Vytautas Petrauskas, Asta Zubrienė, Jurgita Matulienė, Virginija Dudutienė, Edita Čapkauskaitė, Audrius Zakšauskas, Janis Leitans, Saulius Gražulis, Kaspars Tars, Daumantas Matulis
Format: Article
Language:English
Published: International Union of Crystallography 2024-07-01
Series:IUCrJ
Subjects:
drug discovery
protein structure
molecular recognition
x-ray crystallography
intermolecular interactions
carbonic anhydrase isozymes
protein–ligand binding
intrinsic thermodynamics
binding assays
Online Access:https://journals.iucr.org/paper?S2052252524004627

Internet

https://journals.iucr.org/paper?S2052252524004627

Similar Items