Transient receptor potential ankyrin 1 (TRPA1) mediates reactive oxygen species-induced Ca2+ entry, mitochondrial dysfunction, and caspase-3/7 activation in primary cultures of metastatic colorectal carcinoma cells

Transient receptor potential ankyrin 1 (TRPA1) mediates reactive oxygen species-induced Ca2+ entry, mitochondrial dysfunction, and caspase-3/7 activation in primary cultures of metastatic colorectal carcinoma cells

Abstract Colorectal carcinoma (CRC) represents the fourth most common cancer worldwide and is the third most common cause of malignancy-associated mortality. Distant metastases to the liver and lungs are the main drivers of CRC-dependent death. Pro-oxidant therapies, which halt disease progression b...

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Main Authors: Pawan Faris, Agnese Rumolo, Giorgia Pellavio, Matteo Tanzi, Mauro Vismara, Roberto Berra-Romani, Andrea Gerbino, Salvatore Corallo, Paolo Pedrazzoli, Umberto Laforenza, Daniela Montagna, Francesco Moccia
Format: Article
Language:English
Published: Nature Publishing Group 2023-07-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-023-01530-x

Internet

https://doi.org/10.1038/s41420-023-01530-x

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