Microfluidic and Static Organotypic Culture Systems to Support Ex Vivo Spermatogenesis From Prepubertal Porcine Testicular Tissue: A Comparative Study

Microfluidic and Static Organotypic Culture Systems to Support Ex Vivo Spermatogenesis From Prepubertal Porcine Testicular Tissue: A Comparative Study

Background:In vitro maturation of immature testicular tissue (ITT) cryopreserved for fertility preservation is a promising fertility restoration strategy. Organotypic tissue culture proved successful in mice, leading to live births. In larger mammals, including humans, efficiently reproducing sperma...

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Bibliographic Details
Main Authors: Marc Kanbar, Francesca de Michele, Jonathan Poels, Stéphanie Van Loo, Maria Grazia Giudice, Tristan Gilet, Christine Wyns
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Physiology
Subjects:
spermatogonial stem cells
immature testicular tissue
organotypic culture
microfluidic culture
in vitro spermatogenesis
fertility preservation
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2022.884122/full

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https://www.frontiersin.org/articles/10.3389/fphys.2022.884122/full

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