Causes of altered ventricular mechanics in hypertrophic cardiomyopathy: an in-silico study

Causes of altered ventricular mechanics in hypertrophic cardiomyopathy: an in-silico study

Abstract Background Hypertrophic cardiomyopathy (HCM) is typically caused by mutations in sarcomeric genes leading to cardiomyocyte disarray, replacement fibrosis, impaired contractility, and elevated filling pressures. These varying tissue properties are associated with certain strain patterns that...

Full description

Bibliographic Details
Main Authors: Ekaterina Kovacheva, Tobias Gerach, Steffen Schuler, Marco Ochs, Olaf Dössel, Axel Loewe
Format: Article
Language:English
Published: BMC 2021-07-01
Series:BioMedical Engineering OnLine
Subjects:
Hypertrophic cardiomyopathy
In-silico study
Altered mechanics
Active and passive forces
Wall thickness
Fiber disarray
Online Access:https://doi.org/10.1186/s12938-021-00900-9

Internet

https://doi.org/10.1186/s12938-021-00900-9

Similar Items