A novel IRE1 kinase inhibitor for adjuvant glioblastoma treatment

A novel IRE1 kinase inhibitor for adjuvant glioblastoma treatment

Summary: Inositol-requiring enzyme 1 (IRE1) is a major mediator of the unfolded protein response (UPR), which is activated upon endoplasmic reticulum (ER) stress. Tumor cells experience ER stress due to adverse microenvironmental cues, a stress overcome by relying on IRE1 signaling as an adaptive me...

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Bibliographic Details
Main Authors: Diana Pelizzari-Raymundo, Dimitrios Doultsinos, Raphael Pineau, Chloé Sauzay, Thodoris Koutsandreas, Timothy Langlais, Antonio Carlesso, Elena Gkotsi, Luc Negroni, Tony Avril, Aristotelis Chatziioannou, Eric Chevet, Leif A. Eriksson, Xavier Guillory
Format: Article
Language:English
Published: Elsevier 2023-05-01
Series:iScience
Subjects:
Medicine
Biological sciences
Neuroscience
Molecular neuroscience
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223007642

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http://www.sciencedirect.com/science/article/pii/S2589004223007642

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