p53 dynamics vary between tissues and are linked with radiation sensitivity

p53 dynamics vary between tissues and are linked with radiation sensitivity

p53 mediates the response to irradiation, however, tissues with similar levels of p53 have different radiation sensitivities. Here, the authors show that the in vivo p53 dynamics varies in these tissues after radiation, and the use of Mdm2 inhibitor to sustain p53 activity enhances radiosensitivity.

Bibliographic Details
Main Authors: Jacob Stewart-Ornstein, Yoshiko Iwamoto, Miles A. Miller, Mark A. Prytyskach, Stephane Ferretti, Philipp Holzer, Joerg Kallen, Pascal Furet, Ashwini Jambhekar, William C. Forrester, Ralph Weissleder, Galit Lahav
Format: Article
Language:English
Published: Nature Portfolio 2021-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-21145-z

Internet

https://doi.org/10.1038/s41467-021-21145-z

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