p53 dynamics vary between tissues and are linked with radiation sensitivity
p53 mediates the response to irradiation, however, tissues with similar levels of p53 have different radiation sensitivities. Here, the authors show that the in vivo p53 dynamics varies in these tissues after radiation, and the use of Mdm2 inhibitor to sustain p53 activity enhances radiosensitivity.
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-02-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-21145-z |
| _version_ | 1818750583500177408 |
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| author | Jacob Stewart-Ornstein Yoshiko Iwamoto Miles A. Miller Mark A. Prytyskach Stephane Ferretti Philipp Holzer Joerg Kallen Pascal Furet Ashwini Jambhekar William C. Forrester Ralph Weissleder Galit Lahav |
| author_facet | Jacob Stewart-Ornstein Yoshiko Iwamoto Miles A. Miller Mark A. Prytyskach Stephane Ferretti Philipp Holzer Joerg Kallen Pascal Furet Ashwini Jambhekar William C. Forrester Ralph Weissleder Galit Lahav |
| author_sort | Jacob Stewart-Ornstein |
| collection | DOAJ |
| description | p53 mediates the response to irradiation, however, tissues with similar levels of p53 have different radiation sensitivities. Here, the authors show that the in vivo p53 dynamics varies in these tissues after radiation, and the use of Mdm2 inhibitor to sustain p53 activity enhances radiosensitivity. |
| first_indexed | 2024-12-18T04:21:59Z |
| format | Article |
| id | doaj.art-ec4f9099e0ec49f6920b6fbb19143619 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-18T04:21:59Z |
| publishDate | 2021-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-ec4f9099e0ec49f6920b6fbb191436192022-12-21T21:21:13ZengNature PortfolioNature Communications2041-17232021-02-0112111110.1038/s41467-021-21145-zp53 dynamics vary between tissues and are linked with radiation sensitivityJacob Stewart-Ornstein0Yoshiko Iwamoto1Miles A. Miller2Mark A. Prytyskach3Stephane Ferretti4Philipp Holzer5Joerg Kallen6Pascal Furet7Ashwini Jambhekar8William C. Forrester9Ralph Weissleder10Galit Lahav11Department of Systems Biology and the Ludwig Center at Harvard, Blavatnik Institute at Harvard Medical SchoolCenter for Systems Biology, Massachusetts General HospitalCenter for Systems Biology, Massachusetts General HospitalCenter for Systems Biology, Massachusetts General HospitalNovartis Institutes for Biomedical ResearchNovartis Institutes for Biomedical ResearchNovartis Institutes for Biomedical ResearchNovartis Institutes for Biomedical ResearchDepartment of Systems Biology and the Ludwig Center at Harvard, Blavatnik Institute at Harvard Medical SchoolChemical Biology and Therapeutics, Novartis Institutes for Biomedical ResearchDepartment of Systems Biology and the Ludwig Center at Harvard, Blavatnik Institute at Harvard Medical SchoolDepartment of Systems Biology and the Ludwig Center at Harvard, Blavatnik Institute at Harvard Medical Schoolp53 mediates the response to irradiation, however, tissues with similar levels of p53 have different radiation sensitivities. Here, the authors show that the in vivo p53 dynamics varies in these tissues after radiation, and the use of Mdm2 inhibitor to sustain p53 activity enhances radiosensitivity.https://doi.org/10.1038/s41467-021-21145-z |
| spellingShingle | Jacob Stewart-Ornstein Yoshiko Iwamoto Miles A. Miller Mark A. Prytyskach Stephane Ferretti Philipp Holzer Joerg Kallen Pascal Furet Ashwini Jambhekar William C. Forrester Ralph Weissleder Galit Lahav p53 dynamics vary between tissues and are linked with radiation sensitivity Nature Communications |
| title | p53 dynamics vary between tissues and are linked with radiation sensitivity |
| title_full | p53 dynamics vary between tissues and are linked with radiation sensitivity |
| title_fullStr | p53 dynamics vary between tissues and are linked with radiation sensitivity |
| title_full_unstemmed | p53 dynamics vary between tissues and are linked with radiation sensitivity |
| title_short | p53 dynamics vary between tissues and are linked with radiation sensitivity |
| title_sort | p53 dynamics vary between tissues and are linked with radiation sensitivity |
| url | https://doi.org/10.1038/s41467-021-21145-z |
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