ER-Stress and Senescence Coordinately Promote Endothelial Barrier Dysfunction in Diabetes-Induced Atherosclerosis

ER-Stress and Senescence Coordinately Promote Endothelial Barrier Dysfunction in Diabetes-Induced Atherosclerosis

Diabetes mellitus is hallmarked by accelerated atherosclerosis, a major cause of mortality among patients with diabetes. Efficient therapies for diabetes-associated atherosclerosis are absent. Accelerated atherosclerosis in diabetic patients is associated with reduced endothelial thrombomodulin (TM)...

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Bibliographic Details
Main Authors: Sameen Fatima, Saira Ambreen, Akash Mathew, Ahmed Elwakiel, Anubhuti Gupta, Kunal Singh, Shruthi Krishnan, Rajiv Rana, Hamzah Khawaja, Dheerendra Gupta, Jayakumar Manoharan, Christian Besler, Ulrich Laufs, Shrey Kohli, Berend Isermann, Khurrum Shahzad
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Nutrients
Subjects:
atherosclerosis
diabetes
senescence
unfolded protein response
endothelial cells
activated protein C
Online Access:https://www.mdpi.com/2072-6643/14/14/2786

Internet

https://www.mdpi.com/2072-6643/14/14/2786

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