6-Furopyridine Hexamethylene Amiloride Is a Non-Selective P2X7 Receptor Antagonist

6-Furopyridine Hexamethylene Amiloride Is a Non-Selective P2X7 Receptor Antagonist

P2X7 is an extracellular adenosine 5′-triphopshate (ATP)-gated cation channel present on leukocytes, where its activation induces pro-inflammatory cytokine release and ectodomain shedding of cell surface molecules. Human P2X7 can be partially inhibited by amiloride and its derivatives at micromolar...

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Bibliographic Details
Main Authors: Peter Cuthbertson, Amal Elhage, Dena Al-Rifai, Reece A. Sophocleous, Ross J. Turner, Ashraf Aboelela, Hiwa Majed, Richard S. Bujaroski, Iman Jalilian, Michael J. Kelso, Debbie Watson, Benjamin J. Buckley, Ronald Sluyter
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Biomolecules
Subjects:
P2X7 receptor
P2X4 receptor
P2Y receptor
purinergic signalling
amiloride
T cell
Online Access:https://www.mdpi.com/2218-273X/12/9/1309

Internet

https://www.mdpi.com/2218-273X/12/9/1309

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