Extracellular matrix and Hippo signaling as therapeutic targets of antifibrotic compounds for uterine fibroids

Extracellular matrix and Hippo signaling as therapeutic targets of antifibrotic compounds for uterine fibroids

Abstract Background Uterine fibroids are highly prevalent, collagen‐rich, mechanically stiff, fibrotic tumors for which new therapeutic options are needed. Increased extracellular matrix (ECM) stiffness activates mechanical signaling and Hippo/YAP promoting fibroid growth, but no prior studies have...

Full description

Bibliographic Details
Main Authors: Md Soriful Islam, Sadia Afrin, Bhuchitra Singh, Friederike L. Jayes, Joshua T. Brennan, Mostafa A. Borahay, Phyllis C. Leppert, James H. Segars
Format: Article
Language:English
Published: Wiley 2021-07-01
Series:Clinical and Translational Medicine
Subjects:
collagenase
extracellular matrix
Hippo signaling
nintedanib
uterine fibroids
verteporfin
Online Access:https://doi.org/10.1002/ctm2.475

Internet

https://doi.org/10.1002/ctm2.475

Similar Items