Engineering Saccharomyces cerevisiae for the de novo Production of Halogenated Tryptophan and Tryptamine Derivatives

Engineering Saccharomyces cerevisiae for the de novo Production of Halogenated Tryptophan and Tryptamine Derivatives

Abstract The indole scaffold is a recurring structure in multiple bioactive heterocycles and natural products. Substituted indoles like the amino acid tryptophan serve as a precursor for a wide range of natural products with pharmaceutical or agrochemical applications. Inspired by the versatility of...

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Bibliographic Details
Main Authors: Dr. Nicholas Milne, Javier Sáez‐Sáez, Annette Munch Nielsen, Dr. Jane Dannow Dyekjær, Dr. Daniela Rago, Dr. Mette Kristensen, Dr. Tune Wulff, Prof. Dr. Irina Borodina
Format: Article
Language:English
Published: Wiley-VCH 2023-04-01
Series:ChemistryOpen
Subjects:
halogenases
indole
in vivo halogenation
metabolic engineering
Saccharomyces cerevisiae
Online Access:https://doi.org/10.1002/open.202200266

Internet

https://doi.org/10.1002/open.202200266

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