27-hydroxycholesterol and DNA damage repair: implication in prostate cancer

27-hydroxycholesterol and DNA damage repair: implication in prostate cancer

IntroductionWe previously reported that cholesterol homeostasis in prostate cancer (PC) is regulated by 27-hydroxycholesterol (27HC) and that CYP27A1, the enzyme that converts cholesterol to 27HC, is frequently lost in PCs. We observed that restoring the CYP27A1/27HC axis inhibited PC growth. In thi...

Full description

Bibliographic Details
Main Authors: Gloria Cecilia Galvan, Nadine A. Friedrich, Sanjay Das, James P. Daniels, Sara Pollan, Shweta Dambal, Ryusuke Suzuki, Sergio E. Sanders, Sungyong You, Hisashi Tanaka, Yeon-Joo Lee, Wei Yuan, Johann S. de Bono, Irina Vasilevskaya, Karen E. Knudsen, Michael R. Freeman, Stephen J. Freedland
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-12-01
Series:Frontiers in Oncology
Subjects:
27-hydroxycholesterol (27HC)
prostate cancer
hydroxycholesterol
LNCaP (prostate cancer cell)
CYP27A1
DU145 (prostate) cancer cell line
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2023.1251297/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2023.1251297/full

Similar Items