Sildenafil (Viagra) Aggravates the Development of Experimental Abdominal Aortic Aneurysm

Sildenafil (Viagra) Aggravates the Development of Experimental Abdominal Aortic Aneurysm

Background cGMP‐hydrolyzing phosphodiesterase type 5 (PDE5) regulates vascular smooth muscle cell (SMC) contraction by antagonizing cGMP‐dependent protein kinase I (PKGI)–dependent SMC relaxation. SMC contractile dysfunction is implicated in the pathogenesis of aortic aneurysm. PDE5 inhibitors have...

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Bibliographic Details
Main Authors: Chongyang Zhang, Amy Mohan, Hangchuan Shi, Chen Yan
Format: Article
Language:English
Published: Wiley 2022-01-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
abdominal aortic aneurysm
elastase
elastin degradation
sildenafil
Viagra
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.121.023053

Internet

https://www.ahajournals.org/doi/10.1161/JAHA.121.023053

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