Identification of molecular signatures defines the differential proteostasis response in induced spinal and cranial motor neurons

Identification of molecular signatures defines the differential proteostasis response in induced spinal and cranial motor neurons

Summary: Amyotrophic lateral sclerosis damages proteostasis, affecting spinal and upper motor neurons earlier than a subset of cranial motor neurons. To aid disease understanding, we exposed induced cranial and spinal motor neurons (iCrMNs and iSpMNs) to proteotoxic stress, under which iCrMNs showed...

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Bibliographic Details
Main Authors: Ana Paula Zen Petisco Fiore, Shuvadeep Maity, Lauren Jeffery, Disi An, Justin Rendleman, Dylan Iannitelli, Hyungwon Choi, Esteban Mazzoni, Christine Vogel
Format: Article
Language:English
Published: Elsevier 2024-03-01
Series:Cell Reports
Subjects:
motor neurons
amyotrophic lateral sclerosis
Ublcp1
unfolded protein response
proteasome
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124724002134

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http://www.sciencedirect.com/science/article/pii/S2211124724002134

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