B cells infected with Type 2 Epstein-Barr virus (EBV) have increased NFATc1/NFATc2 activity and enhanced lytic gene expression in comparison to Type 1 EBV infection.

B cells infected with Type 2 Epstein-Barr virus (EBV) have increased NFATc1/NFATc2 activity and enhanced lytic gene expression in comparison to Type 1 EBV infection.

Humans are infected with two distinct strains (Type 1 (T1) and Type 2 (T2)) of Epstein-Barr virus (EBV) that differ substantially in their EBNA2 and EBNA 3A/B/C latency genes and the ability to transform B cells in vitro. While most T1 EBV strains contain the "prototype" form of the BZLF1...

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Bibliographic Details
Main Authors: James C Romero-Masters, Shane M Huebner, Makoto Ohashi, Jillian A Bristol, Bayleigh E Benner, Elizabeth A Barlow, Gail L Turk, Scott E Nelson, Dana C Baiu, Nicholas Van Sciver, Erik A Ranheim, Jenny Gumperz, Nathan M Sherer, Paul J Farrell, Eric C Johannsen, Shannon C Kenney
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-02-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1008365

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https://doi.org/10.1371/journal.ppat.1008365

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