Quantitative MRI susceptibility mapping reveals cortical signatures of changes in iron, calcium and zinc in malformations of cortical development in children with drug-resistant epilepsy

Quantitative MRI susceptibility mapping reveals cortical signatures of changes in iron, calcium and zinc in malformations of cortical development in children with drug-resistant epilepsy

Objective: Malformations of cortical development (MCD), including focal cortical dysplasia (FCD), are the most common cause of drug-resistant focal epilepsy in children. Histopathological lesion characterisation demonstrates abnormal cell types and lamination, alterations in myelin (typically co-loc...

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Bibliographic Details
Main Authors: Sara Lorio, Jan Sedlacik, Po-Wah So, Harold G. Parkes, Roxana Gunny, Ulrike Löbel, Yao-Feng Li, Olumide Ogunbiyi, Talisa Mistry, Emma Dixon, Sophie Adler, J. Helen Cross, Torsten Baldeweg, Thomas S. Jacques, Karin Shmueli, David W Carmichael
Format: Article
Language:English
Published: Elsevier 2021-09-01
Series:NeuroImage
Subjects:
Focal cortical dysplasia
Malformation of cortical development
Quantitative magnetic susceptibility
Drug-resistant epilepsy
Brain mineral content
Online Access:http://www.sciencedirect.com/science/article/pii/S1053811921003797

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http://www.sciencedirect.com/science/article/pii/S1053811921003797

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